Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all PDCD5 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5. The immunogen is located within the first 50 amino acids of PDCD5. Amino Acid Squence: QEAKHREAEMRNS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PDCD5 Antibody - BSA Free

Western Blot: PDCD5 AntibodyBSA Free [NBP1-76991]

Western Blot: PDCD5 AntibodyBSA Free [NBP1-76991]

Western Blot: PDCD5 Antibody [NBP1-76991] - Analysis of PDCD5 in Jurkat cell lysate with PDCD5 antibody at 2.5 ug/mL.
Immunocytochemistry/ Immunofluorescence: PDCD5 Antibody - BSA Free [NBP1-76991]

Immunocytochemistry/ Immunofluorescence: PDCD5 Antibody - BSA Free [NBP1-76991]

Immunocytochemistry/Immunofluorescence: PDCD5 Antibody [NBP1-76991] - Jurkat cells with PDCD5 antibody at 5 ug/ml.

Applications for PDCD5 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5 ug/ml

Western Blot

2.5 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDCD5

Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Long Name

Programmed Cell Death 5

Alternate Names

PD5, TFAR19

Gene Symbol

PDCD5

UniProt

O14737 (Human)

Additional PDCD5 Products

Product Documents for PDCD5 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PDCD5 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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