PDE1A Antibody (OTI7D5)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46355

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # OTI7D5

Concentration

1 mg/ml

View all PDE1A Antibodies »

Product Specifications

Immunogen

Human recombinant protein fragment corresponding to amino acids 259-545 of human PDE1A (NP_005010) produced in E.coli.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for PDE1A Antibody (OTI7D5)

Western Blot: PDE1A Antibody (OTI7D5) [NBP2-46355]

Western Blot: PDE1A Antibody (OTI7D5) [NBP2-46355]

Western Blot: PDE1A Antibody (7D5) [NBP2-46355] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE1A .
Immunohistochemistry: PDE1A Antibody (OTI7D5) [NBP2-46355]

Immunohistochemistry: PDE1A Antibody (OTI7D5) [NBP2-46355]

Immunohistochemistry: PDE1A Antibody (7D5) [NBP2-46355] - Analysis of Carcinoma of Human prostate tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min)
Immunohistochemistry: PDE1A Antibody (OTI7D5) [NBP2-46355]

Immunohistochemistry: PDE1A Antibody (OTI7D5) [NBP2-46355]

Immunohistochemistry: PDE1A Antibody (7D5) [NBP2-46355] - Analysis of Adenocarcinoma of Human breast tissue using PDE1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min)
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Applications for PDE1A Antibody (OTI7D5)

Application
Recommended Usage

Immunohistochemistry

1:150

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PDE1A

PDE1A, a variant of PDE1, is a Ca2+-calmodulin-stimulated phosphodieterase (PDE) preferentially hydrolyzing cGMP. Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, B, and C). PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. The PDE1A gene family includes various proteins that differ from each other at amino and carboxy termini of the protein.

Long Name

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

Alternate Names

61 kDa Cam-PDE, Cam-PDE 1A, hCam-1

Gene Symbol

PDE1A

Additional PDE1A Products

Product Documents for PDE1A Antibody (OTI7D5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PDE1A Antibody (OTI7D5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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