PDZK1 Antibody (SR2158)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22197

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22197-100ul
NBP3-22197-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2158

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PDZK1 Antibodies »

Product Summary for PDZK1 Antibody (SR2158)

Immunogen

A synthesized peptide derived from human PDZK1 (Uniprot #: Q5T2W1)

Specificity

Detects endogenous levels of total PDZK1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PDZK1 Antibody (SR2158)

Western Blot: PDZK1 Antibody (SR2158) [NBP3-22197] -

Western Blot: PDZK1 Antibody (SR2158) [NBP3-22197] - Western blot analysis using NBP3-22197 in T47-D cell lysate.

Applications for PDZK1 Antibody (SR2158)

Application
Recommended Usage

Immunoprecipitation

1:50

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDZK1

PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, PDZK1 may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport, therefore playing an important role in tubule function .

Long Name

PDZ Domain Containing 1

Alternate Names

CAP70, CLAMP, NaPi-Cap1, NHERF3, PDZD1

Gene Symbol

PDZK1

Additional PDZK1 Products

Product Documents for PDZK1 Antibody (SR2158)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PDZK1 Antibody (SR2158)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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