PERP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2912

Novus Biologicals, part of Bio-Techne
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NB100-2912
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all PERP Antibodies »

Product Specifications

Immunogen

Peptide with sequence CLPNYEDDLLGNAK corresponding to C-Terminus according to NP_071404.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PERP Antibody

Western Blot: PERP Antibody [NB100-2912]

Western Blot: PERP Antibody [NB100-2912]

Western Blot: PERP Antibody [NB100-2912] - (1ug/ml) staining of human liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: PERP Antibody [NB100-2912]

Immunohistochemistry-Paraffin: PERP Antibody [NB100-2912]

Immunohistochemistry-Paraffin: PERP Antibody [NB100-2912] - Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for PERP Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml

Peptide ELISA

Detection limit 1:64000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 20 kDa band observed in human liver lysates (calculated MW of 21.4 kDa band according to NP_071404.2).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PERP

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Alternate Names

dJ496H19.1, KCP1KCP-1, Keratinocyte-associated protein 1, KRTCAP11110017A08Rik, p53 apoptosis effector related to PMP22, p53 apoptosis effector related to PMP-22, P53-induced protein PIGPC1, PERP, TP53 apoptosis effector, PIGPC1RP3-496H19.1, THWkeratinocytes associated protein 1, Transmembrane protein THW

Entrez Gene IDs

64065 (Human); 64058 (Mouse); 292949 (Rat)

Gene Symbol

PERP

UniProt

NP_071404.2 (Human)

Additional PERP Products

Product Documents for PERP Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PERP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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