Phospholipid Scramblase 1/PLSCR1 Antibody (3B4)

Novus Biologicals, part of Bio-Techne | Catalog # H00005359-M02

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 3B4

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Phospholipid Scramblase 1/PLSCR1 Antibodies »

Product Specifications

Immunogen

PLSCR1 (AAH32718, 1 a.a. ~ 318 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIKLLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW

Localization

Cell Membrane (single-pass type II membrane protein) and Nuclear.

Specificity

PLSCR1 - phospholipid scramblase 1

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Phospholipid Scramblase 1/PLSCR1 Antibody (3B4)

Immunoprecipitation: Phospholipid Scramblase 1/PLSCR1 Antibody (3B4) [H00005359-M02]

Immunoprecipitation: Phospholipid Scramblase 1/PLSCR1 Antibody (3B4) [H00005359-M02]

Immunoprecipitation: Phospholipid Scramblase 1/PLSCR1 Antibody (3B4) [H00005359-M02] - Analysis of PLSCR1 transfected lysate using anti-PLSCR1 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with PLSCR1 MaxPab rabbit polyclonal antibody.

Applications for Phospholipid Scramblase 1/PLSCR1 Antibody (3B4)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against recombinant protein on ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Phospholipid Scramblase 1/PLSCR1

Phospholipid scramblase 1 (PLSCR1) is a member of the PLSCR protein family. These proteins are ATP-independent lipid translocators localized to the plasma membrane and is involved in a calcium dependent, nonspecific and rapid redistribution (scrambling) of phospholipids when a perturbation of plasma membrane asymmetry is needed for the cell (e.g. following cell activation, injury, or apoptosis). The expression of PLSCR1 is found in a variety of tissue and can be stress-induced. Upon stimulation (e.g. interferon stimulation), a portion of newly synthesized PLSCR1 is imported into the nucleus (instead of inserted into the plasma membrane) and interacts with DNA, consistent with a role in gene regulation. PLSCR1 may be closely associated with the pathophysiology underlying infection and inflammation, which manifest marked changes in energy consumption and lipid metabolism.

Alternate Names

MMTRA1B, PLSCR1

Entrez Gene IDs

5359 (Human)

Gene Symbol

PLSCR1

OMIM

604170 (Human)

UniProt

AAH32718 (Human)

Additional Phospholipid Scramblase 1/PLSCR1 Products

Product Documents for Phospholipid Scramblase 1/PLSCR1 Antibody (3B4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Phospholipid Scramblase 1/PLSCR1 Antibody (3B4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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