Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all PIAS2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human PIAS2. The immunogen is located within amino acids 110 - 160 of PIAS2. Amino Acid Squence: DTKPTFEMQQPSPPIPPV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PIAS2 Antibody - BSA Free

Western Blot: PIAS2 AntibodyBSA Free [NBP1-77159]

Western Blot: PIAS2 AntibodyBSA Free [NBP1-77159]

Western Blot: PIAS2 Antibody [NBP1-77159] - Rat brain tissue lysate with PIAS2 antibody at (A) 1 and (B) 2 ug/mL.
PIAS2 Antibody - BSA Free

Immunohistochemistry: PIAS2 Antibody - BSA Free [NBP1-77159] -

Immunohistochemistry: PIAS2 Antibody - BSA Free [NBP1-77159] - Immunohistochemistry of PIAS2 in rat brain tissue with PIAS2 antibody at 5 u/mL.
PIAS2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: PIAS2 Antibody - BSA Free [NBP1-77159] -

Immunocytochemistry/ Immunofluorescence: PIAS2 Antibody - BSA Free [NBP1-77159] - Immunofluorescence of PIAS2 in rat brain tissue with PIAS2 antibody at 20 u/mL.

Applications for PIAS2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PIAS2

The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.

Long Name

Protein Inhibitor of Activated STAT 2

Alternate Names

ARIP3, DIP, MIZ1, PIASx alpha, SIZ2, ZMIZ4

Gene Symbol

PIAS2

UniProt

EAX01485 (Human)

Additional PIAS2 Products

Product Documents for PIAS2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PIAS2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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