PKC alpha [p Thr638] Antibody (SR2239)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21584

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21584-100ul
NBP3-21584-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2239

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PKC alpha Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-PKC alpha [Thr638] (Uniprot #: P17252)

Modification

p Thr 638

Specificity

Detects endogenous levels of total phospho-PKC alpha [Thr638]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PKC alpha [p Thr638] Antibody (SR2239)

Western Blot: PKC alpha [p Thr 638] Antibody (SR2239) [NBP3-21584] -

Western Blot: PKC alpha [p Thr 638] Antibody (SR2239) [NBP3-21584] - Western blot analysis using NBP3-21584 in (1) Jurkat cell lysate treated with TPA; (2) Jurkat cell lysate.

Applications for PKC alpha [p Thr638] Antibody (SR2239)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:1000-1:5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PKC alpha

Protein Kinase C (PKC) is a large superfamily of serine/threonine kinases that mediate essential cellular signals required for activation, proliferation, differentiation and survival. There are at least ten PKC isotypes that are closely related in structure but that have distinct patterns of tissue distribution and function. The PKC isotypes can be subdivided into three classes based on primary structure and biochemical properties. These are: classical or conventional PKC isotypes (cPKC), novel PKC isotypes (nPKC) and atypical PKC isotypes (aPKC). All PKC isotypes share a characteristic equence motif C1 in addition to a serine/threonine-protein kinase domain. The cPKC isotypes include PKC

Long Name

Protein Kinase C alpha

Alternate Names

PKCA, PRKCA

Gene Symbol

PRKCA

Additional PKC alpha Products

Product Documents for PKC alpha [p Thr638] Antibody (SR2239)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PKC alpha [p Thr638] Antibody (SR2239)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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