PMS2 Antibody (PMS2/4373R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-07615

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-07615-100ug
NBP3-07615-20ug
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # PMS2/4373R

Concentration

0.2 mg/ml

View all PMS2 Antibodies »

Product Summary for PMS2 Antibody (PMS2/4373R)

Immunogen

A synthetic peptide corresponding to residues within aa1-100 of human PMS2 (exact sequence is proprietary) (Uniprot: P54278 )

Localization

Nuclear

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

96 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-08570)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C.

Scientific Data Images for PMS2 Antibody (PMS2/4373R)

Immunohistochemistry-Paraffin: PMS2 Antibody (PMS2/4373R) [NBP3-07615]

Immunohistochemistry-Paraffin: PMS2 Antibody (PMS2/4373R) [NBP3-07615]

Immunohistochemistry-Paraffin: PMS2 Antibody (PMS2/4373R) [NBP3-07615] - Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMS2 Recombinant Rabbit Monoclonal Antibody (PMS2/4373R).
Immunohistochemistry-Paraffin: PMS2 Antibody (PMS2/4373R) [NBP3-07615]

Immunohistochemistry-Paraffin: PMS2 Antibody (PMS2/4373R) [NBP3-07615]

Immunohistochemistry-Paraffin: PMS2 Antibody (PMS2/4373R) [NBP3-07615] - Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMS2 Recombinant Rabbit Monoclonal Antibody (PMS2/4373R).
Protein Array: PMS2 Antibody (PMS2/4373R) [NBP3-07615]

Protein Array: PMS2 Antibody (PMS2/4373R) [NBP3-07615]

Protein Array: PMS2 Antibody (PMS2/4373R) [NBP3-07615] - Analysis of Protein Array containing more than 19,000 full-length human proteins using PMS2-Monospecific Recombinant Rabbit Monoclonal Antibody (PMS2/4373R).

Applications for PMS2 Antibody (PMS2/4373R)

Application
Recommended Usage

Flow Cytometry

1-2 ug/million cells

Immunocytochemistry/ Immunofluorescence

1-2 ug/ml

Immunohistochemistry-Paraffin

1-2 ug/ml

Western Blot

1-2 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: PMS2

PMS2 is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Alternate Names

DNA mismatch repair protein PMS2, EC 3.1, H_DJ0042M02.9, HNPCC4postmeiotic segregation increased (S. cerevisiae) 2, mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae), PMSL2PMS2CL

Gene Symbol

PMS2

UniProt

P54278 (Human)

Additional PMS2 Products

Product Documents for PMS2 Antibody (PMS2/4373R)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PMS2 Antibody (PMS2/4373R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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