Potassium Channel Kv3.1 [p Ser503] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-279

Novus Biologicals, part of Bio-Techne
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NB300-279
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Key Product Details

Species Reactivity

Mouse, Rat, Hamster

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Potassium Channel Kv3.1 Antibodies »

Product Specifications

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH. Accession # P25122

Reactivity Notes

Tested in Rat and Mouse.

Modification

p Ser503

Specificity

Specific for endogenous levels of the ~100 kDa Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Potassium Channel Kv3.1 [p Ser503] Antibody

Immunohistochemistry: Potassium Channel Kv3.1 [p Ser503] Antibody [NB300-279]

Immunohistochemistry: Potassium Channel Kv3.1 [p Ser503] Antibody [NB300-279]

Immunohistochemistry: Kv3.1 [p Ser503] Antibody [NB300-279] - IHC staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503 Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA.

Applications for Potassium Channel Kv3.1 [p Ser503] Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:400

Immunohistochemistry

1:1000

Immunohistochemistry-Frozen

1:1000

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Potassium Channel Kv3.1

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Alternate Names

KCNC1

Entrez Gene IDs

16502 (Mouse); 25327 (Rat)

Gene Symbol

KCNC1

UniProt

P25122 (Rat)

Additional Potassium Channel Kv3.1 Products

Product Documents for Potassium Channel Kv3.1 [p Ser503] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Potassium Channel Kv3.1 [p Ser503] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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