Protein Phosphatase inhibitor 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24490

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP2-24490
NBP2-24490SS
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Validated:

Human, Canine, Equine, Primate

Predicted:

Bovine (100%), Mouse (100%), Rat (100%), Xenopus (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Protein Phosphatase inhibitor 1 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 50-100 of human IPP-1 was used as the immunogen.

Reactivity Notes

Chimpanzee (100%), Chicken (73%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Protein Phosphatase inhibitor 1 Antibody

Western Blot: Protein Phosphatase inhibitor 1 Antibody [NBP2-24490]

Western Blot: Protein Phosphatase inhibitor 1 Antibody [NBP2-24490]

Western Blot: Protein Phosphatase inhibitor 1 Antibody [NBP2-24490] - Analysis of IPP-1 in human ovary lysate in the 1) absence and 2) presence of immunizing peptide using this antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: Protein Phosphatase inhibitor 1 Antibody [NBP2-24490]

Immunohistochemistry-Paraffin: Protein Phosphatase inhibitor 1 Antibody [NBP2-24490]

Immunohistochemistry-Paraffin: Protein Phosphatase inhibitor 1 Antibody [NBP2-24490] - Analysis of human kidney using this antibody at 10 ug/ml.

Applications for Protein Phosphatase inhibitor 1 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.2 ml PBS and 0.2% Gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Protein Phosphatase inhibitor 1

The inhibitor of protein phosphatase 1 (IPP-1, I-1) is an endogenous inhibitor of protein phophastase 1 (PP-1), a signal transducer in many cellular pathways. IPP-1 is a member of heat-stable PP1 inhibitory subunits, which includes DARPP-32, (a homologue of IPP-1) and IPP-2. First discovered in rabbit skeletal muscle, IPP-1 is expressed in various mammalian tissues. IPP-1 inhibition of PP-1 is controlled through phosphorylation at Thr35 by cAMP-dependent protein kinase and a tetra-peptide consensus motif in various PP-1 binding proteins (1). IPP-1 is a hormonal control in muscle contraction, pituitary cell growth, synaptic plasticity by neurotransmitters, and glycogen metabolism (2). In vivo, IPP-1 is phosphorylated at Ser-67 by NCLK, which also initiates inhibition of PP-1 by IPP-1 (3). Triggered by increase in calcium level, IPP-1 is inactivated by PP2B through de-phosphorylation (4).

Alternate Names

I1, I-1, IPP-1, IPP1inhibitor-1, protein phosphatase 1 regulatory subunit 1A, protein phosphatase 1, regulatory (inhibitor) subunit 1A, Protein phosphatase inhibitor 1, protein phosphatase inhibitor-1

Gene Symbol

PPP1R1A

UniProt

Q13522 (Human)

Additional Protein Phosphatase inhibitor 1 Products

Product Documents for Protein Phosphatase inhibitor 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Protein Phosphatase inhibitor 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.