PrPC Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38508

Novus Biologicals, part of Bio-Techne
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NBP2-38508
NBP2-38508-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PrPC Antibodies »

Product Specifications

Immunogen

This antibody was developed against a Recombinant PrPc protein corresponding to amino acids: GSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PrPC Antibody

Immunocytochemistry/ Immunofluorescence: PrPC Antibody [NBP2-38508]

Immunocytochemistry/ Immunofluorescence: PrPC Antibody [NBP2-38508]

Immunocytochemistry/Immunofluorescence: PrPC Antibody [NBP2-38508] - Staining of human cell line U-2 OS shows localization to nuclear membrane & cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: PrPC Antibody [NBP2-38508]

Immunohistochemistry-Paraffin: PrPC Antibody [NBP2-38508]

Immunohistochemistry-Paraffin: PrPC Antibody [NBP2-38508] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: PrPC Antibody [NBP2-38508]

Immunohistochemistry-Paraffin: PrPC Antibody [NBP2-38508]

Immunohistochemistry-Paraffin: PrPC Antibody [NBP2-38508] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
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Applications for PrPC Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PrPC

Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).

Alternate Names

CD230, CJD, fatal familial insomnia), GSS, prion protein, prion protein (p27-30), prion protein PrP, prion-related protein, PRIPMGC26679

Gene Symbol

PRNP

UniProt

P04156 (Human)

Additional PrPC Products

Product Documents for PrPC Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PrPC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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