PSF2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33825

Novus Biologicals, part of Bio-Techne
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NBP2-33825
NBP2-33825-25ul
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Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PSF2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: ELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PSF2 Antibody

Western Blot: PSF2 Antibody [NBP2-33825]

Western Blot: PSF2 Antibody [NBP2-33825]

Western Blot: PSF2 Antibody [NBP2-33825] - Analysis in MCF-7 cells transfected with control siRNA, target specific siRNA probe #1, using Anti-GINS2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
Immunocytochemistry/ Immunofluorescence: PSF2 Antibody [NBP2-33825]

Immunocytochemistry/ Immunofluorescence: PSF2 Antibody [NBP2-33825]

Immunocytochemistry/Immunofluorescence: PSF2 Antibody [NBP2-33825] - Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
Immunohistochemistry-Paraffin: PSF2 Antibody [NBP2-33825]

Immunohistochemistry-Paraffin: PSF2 Antibody [NBP2-33825]

Immunohistochemistry-Paraffin: PSF2 Antibody [NBP2-33825] - Staining of human colon shows moderate nuclear positivity in glandular cells.

Applications for PSF2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PSF2

PSF2, also known as DNA replication complex GINS protein PSF2, is a 185 amino acid protein that is 21 kDa, belongs to the GINS2/PSF2 family, localizes in the nucleus, plays an essential role in the initiation of DNA replication and progression of DNA replication forks, and seems to bind preferentially to single-stranded DNA. This protein is being studied for its involvement in breast cancer. The protein has been also linked to the unwinding of DNA, S Phase, DNA strand elongation, synthesis of DNA, DNA replication, cell cycle, and cell cycle, mitotic pathways where it interacts with CHEK2, GINS4, FANCF, GTF2A1L, KPNA4, LMNB1, and other proteins.

Alternate Names

DNA replication complex GINS protein PSF2, GINS complex subunit 2, GINS complex subunit 2 (Psf2 homolog), HSPC037, PSF2Pfs2

Gene Symbol

GINS2

UniProt

Q9Y248 (Human)

Additional PSF2 Products

Product Documents for PSF2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PSF2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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