PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-45058

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # GCP-05

Format

BSA Free

Concentration

1 mg/ml

View all PSMA/FOLH1/NAALADase I Antibodies »

Product Specifications

Immunogen

amino acids 44-750 of human GCPII

Specificity

The antibody GCP-05 recognizes extracellular domain of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free [NBP1-45058]

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free [NBP1-45058]

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [NBP1-45058] - Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) PE on LNCaP cell line. Image using the PE form of this antibody.
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free [NBP1-45058]

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free [NBP1-45058]

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [NBP1-45058] - Analysis of GCPII (PSMA) by various monoclonal antibodies (GCP-01, GCP-02, GCP-04, GCP-05) on LNCaP cell line. Legend: Green column - 1 ug/ml, LNCaP cell line Blue column - 5 ug/ml, LNCaP cell line Yellow column - negative cell line
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free [NBP1-45058]

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free [NBP1-45058]

Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [NBP1-45058] - Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) Alexa Fluor 488 on LNCaP cell line. Image using the PE form of this antibody.
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Applications for PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free

Application
Recommended Usage

Flow Cytometry

1-4 ug/ml

Immunocytochemistry/ Immunofluorescence

1:10-1:2000

Immunoprecipitation

1:50
Application Notes
This antibody is Cytof ready.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: PSMA/FOLH1/NAALADase I

Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I), folate hydrolase (FOLH1), and prostate-specific membrane antigen (PSMA), is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate, which is released from neurons in a calcium-dependent manner, to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic, GCPII contributes to pathological conditions regarding e.g. Alzheimer's disease, Huntington's disease, epilepsy, schizophrenia, stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate, enabling folate to be absorbed by gastrointestinal tract. GCPII, which is present in a number of tissues at low levels, is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM') than mRNA for membrane-bound GCPII, and this ratio is reversed upon malignant transformation.

Long Name

Prostate-specific Membrane Antigen

Alternate Names

FGCP, FOLH1, GCP2, GCPII, mopsm, NAALAD1, NAALADase I

Gene Symbol

FOLH1

Additional PSMA/FOLH1/NAALADase I Products

Product Documents for PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PSMA/FOLH1/NAALADase I Antibody (GCP-05) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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