PTH Antibody (3H9 + PTH/1175) - C-terminus, N-terminal

Validated:

Unconjugated

Monoclonal Mouse IgG2b Kappa/IgG2b Kappa Clone # 3H9 + PTH/1175

0.2 mg/ml

A synthetic peptide around aa 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary) (3H9); A recombinant fragment around aa 32-115 of human mature PTH-polypeptide (exact sequence is proprietary) (Uniprot: P01270)

Predicted to react with Mouse. Rat. Rabbit. Bovine. Canine. Porcine. Deer. Orangutan.

Cytoplasmic and Secreted

Epitope of this monoclonal antibody maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Monoclonal

Mouse

IgG2b Kappa/IgG2b Kappa

9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-47731)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Protein A or G purified

10 mM PBS with 0.05% BSA

0.05% Sodium Azide

0.2 mg/ml

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C.