PTP alpha/PTPRA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89683

Novus Biologicals, part of Bio-Techne
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NBP1-89683
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PTP alpha/PTPRA Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: IWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGM

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23448979)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PTP alpha/PTPRA Antibody

Western Blot: PTP alpha/PTPRA Antibody [NBP1-89683]

Western Blot: PTP alpha/PTPRA Antibody [NBP1-89683]

Western Blot: PTP alpha/PTPRA Antibody [NBP1-89683] - Analysis in control (vector only transfected HEK293T lysate) and PTPRA over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry: PTP alpha/PTPRA Antibody [NBP1-89683]

Immunohistochemistry: PTP alpha/PTPRA Antibody [NBP1-89683]

Immunohistochemistry: PTP alpha/PTPRA Antibody [NBP1-89683] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes.

Applications for PTP alpha/PTPRA Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PTP alpha/PTPRA

PTP alpha is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Long Name

Protein Tyrosine Phosphatase Receptor-type alpha

Alternate Names

HEPTP, HLPR, LRP, PTPase-alpha, PTPRA, PTPRL2

Gene Symbol

PTPRA

Additional PTP alpha/PTPRA Products

Product Documents for PTP alpha/PTPRA Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PTP alpha/PTPRA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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