PTP alpha/PTPRA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14454

Novus Biologicals, part of Bio-Techne
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NBP3-14454
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all PTP alpha/PTPRA Antibodies »

Product Specifications

Immunogen

Synthetic 17 amino acid peptide from extracellular domain of human PTP alpha/PTPRA.

Epitope

Extracellular Domain

Reactivity Notes

Expected reactivity based on percent sequence identity: Hamster, Canine, Bovine, Rabbit (88%), Mouse, Equine (82%)

Specificity

Human PTP alpha/PTPRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for PTP alpha/PTPRA Antibody

Immunohistochemistry: PTP alpha/PTPRA Antibody [NBP3-14454]

Immunohistochemistry: PTP alpha/PTPRA Antibody [NBP3-14454]

Immunohistochemistry: PTP alpha/PTPRA Antibody [NBP3-14454] - Immunohistochemistry of lung, non-small cell carcinoma,
Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NBP3-14454]

Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NBP3-14454]

Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NBP3-14454] - Immunohistochemistry of formalin-fixed, paraffin-embedded human skeletal muscle after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NBP3-14454]

Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NBP3-14454]

Immunohistochemistry-Paraffin: PTP alpha/PTPRA Antibody [NBP3-14454] - Immunohistochemistry of formalin-fixed, paraffin-embedded human skin melanoma after heat-induced antigen retrieval.
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Applications for PTP alpha/PTPRA Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 15 ug/ml..

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: PTP alpha/PTPRA

PTP alpha is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Long Name

Protein Tyrosine Phosphatase Receptor-type alpha

Alternate Names

HEPTP, HLPR, LRP, PTPase-alpha, PTPRA, PTPRL2

Gene Symbol

PTPRA

Additional PTP alpha/PTPRA Products

Product Documents for PTP alpha/PTPRA Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PTP alpha/PTPRA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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