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PTP mu/PTPRM Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-79867

Novus Biologicals, part of Bio-Techne
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NB100-79867

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

Product Specifications

Immunogen

Peptide with sequence C-KLIRQVDKWQEEYN corresponding to internal region according to NP_001098714.1, NP_002836.3.

Epitope

KLIRQVDKWQEEYN

Reactivity Notes

Expected from sequence similarity: Mouse, Dog

Specificity

This antibody is expected to recognise both reported isoforms (NP_001098714.1 and NP_002836.3).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PTP mu/PTPRM Antibody

Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB100-79867]

Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB100-79867]

Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB100-79867] - (3.75ug/ml) staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB100-79867]

Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB100-79867]

Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB100-79867] - (3.75ug/ml) staining of paraffin embedded Human Thyroid. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for PTP mu/PTPRM Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

3.75 ug/ml

Peptide ELISA

Detection limit 1:16000
Application Notes
WB: Preliminary experiments gave bands at approx. 110 kDa band and 16 kDa band in rat retina lysates after 0.1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 165 kDa band according to human NP_001098714.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PTP mu/PTPRM

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

Long Name

Protein Tyrosine Phosphatase Receptor-type M

Alternate Names

PTPRL1, PTPRM, R-PTP-mu

Entrez Gene IDs

5797 (Human); 19274 (Mouse)

Gene Symbol

PTPRM

Additional PTP mu/PTPRM Products

Product Documents for PTP mu/PTPRM Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PTP mu/PTPRM Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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