Rab3A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3335

Novus Biologicals, part of Bio-Techne
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NB120-3335
NB120-3335-0.025mg
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all Rab3A Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues M(1) A S A T D S R Y G Q K E S S D Q N(18) C of human RAB3A.

Reactivity Notes

Cross-reacts with Hamster.

Specificity

Rab3A

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Rab3A Antibody

Western Blot: Rab3A Antibody [NB120-3335]

Western Blot: Rab3A Antibody [NB120-3335]

Western Blot: Rab3A Antibody [NB120-3335] - Analysis of Hepa1 cell lysate.

Applications for Rab3A Antibody

Application
Recommended Usage

Flow Cytometry

3 - 5 ug / 10^6 cells

Immunocytochemistry/ Immunofluorescence

2 ug/ml

Immunoprecipitation

1:10 - 1:500

Western Blot

2 ug/ml
Application Notes
WB: Detects an approx. 21 kDa protein representing Rab 3A from Hepa1 cell lysate.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Rab3A

Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in co-ordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals and the best studied is rab 3A. Rab 3A is found to be abundant in presynaptic nerve terminals and is also found to be crucial in acrosomal exocytosis in human spermatozoa. Abnormal accumulation of rab 3A in the cytoplasm of Purkinje cells has been reported in the prion protein related Creutzfeldt-Jakob disease.

Alternate Names

RAB3A, member RAS oncogene family, RAS-associated protein RAB3A, ras-related protein Rab-3A

Entrez Gene IDs

5864 (Human); 19339 (Mouse); 25531 (Rat)

Gene Symbol

RAB3A

Additional Rab3A Products

Product Documents for Rab3A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Rab3A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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