Rad17 [p Ser645] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24457

Novus Biologicals, part of Bio-Techne
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NBP2-24457
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse, Primate

Predicted:

Bovine (94%), Canine (94%), Chimpanzee (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all Rad17 Antibodies »

Product Specifications

Immunogen

A portion of human Rad17 protein containing a phosphorylated serine residue at position 645 was used as the immunogen.

Modification

p Ser645

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Rad17 [p Ser645] Antibody

Western Blot: Rad17 [p Ser645] Antibody [NBP2-24457]

Western Blot: Rad17 [p Ser645] Antibody [NBP2-24457]

Western Blot: Rad17 [p Ser645] Antibody [NBP2-24457] - analysis of phosphorylated Rad17 (Ser645) in 1) untreated PANC-1 cells (a human pancreatic carcinoma) and 2) UV-treated PANC-1 cells using this antibody at 0.5 ug/ml.
Western Blot: Rad17 [p Ser645] Antibody [NBP2-24457]

Western Blot: Rad17 [p Ser645] Antibody [NBP2-24457]

Western Blot: Rad17 [p Ser645] Antibody [NBP2-24457] - Western blot analysis of phosphorylated Rad17 (Ser645) in recombinant fusion protein containing 1) a phosphorylated serine at position 645 and 2) an unphosphorylated serine at position 645 using NBP2-24457 at 0.025 ug/ml.
Immunohistochemistry-Paraffin: Rad17 [p Ser645] Antibody [NBP2-24457]

Immunohistochemistry-Paraffin: Rad17 [p Ser645] Antibody [NBP2-24457]

Immunohistochemistry-Paraffin: Rad17 [p Ser645] Antibody [NBP2-24457] - Analysis of phosphorylated Rad17 in formalin-fixed, paraffin-embedded mouse liver tissue using an isotype control (top) and this antibody (bottom) at 5 ug/ml.

Applications for Rad17 [p Ser645] Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.025-1 ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.1 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Rad17

Signals originating from damaged DNA activate checkpoint pathways and target the mitotic apparatus via a number a distinct mechanisms. These checkpoints link damage to DNA with the components of the cell cycle through signal transduction systems. In mammals, five genes have been identified as components of DNA damage-induced checkpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma. When overexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulation of G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpoint pathway.(1).

Alternate Names

CCYC, cell cycle checkpoint protein (RAD17), cell cycle checkpoint protein RAD17, FLJ41520, hRad17, R24L, RAD1 (S. pombe) homolog, RAD1 homolog, RAD17 homolog (S. pombe), Rad17-like protein, RAD17Sp, Rad24, RF-C activator 1 homolog, RF-C/activator 1 homolog

Gene Symbol

RAD17

UniProt

O75943

Additional Rad17 Products

Product Documents for Rad17 [p Ser645] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Rad17 [p Ser645] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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