RanBP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-93338

Novus Biologicals, part of Bio-Techne
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NB100-93338
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all RanBP2 Antibodies »

Product Summary for RanBP2 Antibody

Immunogen

The immunogen recognized by this antibody maps to a region between residue 2600 and 2650 of human RAN binding protein 2 using the numbering given in entry NP_006258.3 (GeneID 5903).

Reactivity Notes

Chimpanzee (100%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

358 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RanBP2 Antibody

Western Blot: RanBP2 Antibody [NB100-93338]

Western Blot: RanBP2 Antibody [NB100-93338]

Western Blot: RanBP2 Antibody [NB100-93338] - Detection of Human RanBP2 on HeLa whole cell lysate using NB100-93338. RanBP2 was also immunoprecipitated by rabbit anti-RanBP2 antibody NB100-93337.

Applications for RanBP2 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: RanBP2

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq]

Alternate Names

ANE1, E3 SUMO-protein ligase RanBP2, EC 5.2.1.8, Nuclear pore complex protein Nup358, nucleoporin 358, Nucleoporin Nup358, NUP358TRP2, p270, RAN binding protein 2, Ran-binding protein 2, RanBP2, transformation-related protein 2,358 kDa nucleoporin, TRP1

Entrez Gene IDs

5903 (Human)

Gene Symbol

RANBP2

UniProt

P49792 (Human)

Additional RanBP2 Products

Product Documents for RanBP2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RanBP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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