Ret Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84568

Novus Biologicals, part of Bio-Techne
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NBP1-84568
NBP1-84568-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Ret Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: NQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM

Reactivity Notes

Reactivity reported in scientific literature (PMID: 22751117)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Ret Antibody

Immunocytochemistry/ Immunofluorescence: Ret Antibody [NBP1-84568]

Immunocytochemistry/ Immunofluorescence: Ret Antibody [NBP1-84568]

Immunocytochemistry/Immunofluorescence: Ret Antibody [NBP1-84568] - Staining of human cell line U-251 MG shows localization to cytosol & vesicles. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Ret Antibody [NBP1-84568]

Immunohistochemistry-Paraffin: Ret Antibody [NBP1-84568]

Immunohistochemistry-Paraffin: Ret Antibody [NBP1-84568] - Staining of human gastrointestinal shows strong membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: Ret Antibody [NBP1-84568]

Immunohistochemistry-Paraffin: Ret Antibody [NBP1-84568]

Immunohistochemistry-Paraffin: Ret Antibody [NBP1-84568] - Staining of human adrenal gland shows cytoplasmic membranous positivity in glandular cells.
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Applications for Ret Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Ret

Ret, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Long Name

Proto-oncogene Tyrosine-protein Kinase Receptor Ret

Alternate Names

CDHF12MTC1, CDHR16, EC 2.7.10, Hirschsprung disease 1, Hirschsprung disease), MEN2A, MEN2B, multiple endocrine neoplasia and medullary thyroid carcinoma 1, ret proto-oncogene, RET transforming sequence

Entrez Gene IDs

5979 (Human); 19713 (Mouse); 24716 (Rat)

Gene Symbol

RET

UniProt

P07949

Additional Ret Products

Product Documents for Ret Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Ret Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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