RIMS2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76905

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all RIMS2 Antibodies »

Product Summary for RIMS2 Antibody - BSA Free

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2. The immunogen is located within amino acids 250 - 300 of Rim2. Amino Acid Squence: DRKRSPSVSRDQNRRYD

Specificity

Multiple isoforms of RIM2 are known to exist. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

128 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RIMS2 Antibody - BSA Free

Western Blot: RIMS2 AntibodyBSA Free [NBP1-76905]

Western Blot: RIMS2 AntibodyBSA Free [NBP1-76905]

Western Blot: RIMS2 Antibody [NBP1-76905] - Analysis in human brain tissue lysate with antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: RIMS2 Antibody - BSA Free [NBP1-76905]

Immunocytochemistry/ Immunofluorescence: RIMS2 Antibody - BSA Free [NBP1-76905]

Immunocytochemistry/Immunofluorescence: RIMS2 Antibody [NBP1-76905] - Immunofluorescence of Rim2 in Human Brain cells with Rim2 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: RIMS2 Antibody - BSA Free [NBP1-76905]

Immunohistochemistry-Paraffin: RIMS2 Antibody - BSA Free [NBP1-76905]

Immunohistochemistry-Paraffin: RIMS2 Antibody [NBP1-76905] - Human brain with Rims2 antibody at 5 ug/mL.

Applications for RIMS2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RIMS2

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. Rim2 is known to exist in multiple isoforms; this antibody should recognize most of them. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Alternate Names

DKFZp781A0653, KIAA0751RIM2OBOERAB3 interacting protein 3, non-small cell lung cancer RimL3a protein, non-small cell lung cancer RimL3c protein, nuclear protein, Rab-3-interacting molecule 2, rab3-interacting molecule 2, Rab-3-interacting protein 3, RAB3IP3, regulating synaptic membrane exocytosis 2, regulating synaptic membrane exocytosis protein 2, RIM 2

Gene Symbol

RIMS2

UniProt

NP_001093587 (Human)

Additional RIMS2 Products

Product Documents for RIMS2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RIMS2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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