RIP140 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB110-5122

Novus Biologicals, part of Bio-Techne
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NB110-5122
NB110-5122-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all RIP140 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues G(718) N P T K G R V K K K E K T P L R D(735) of human RIP140.

Reactivity Notes

Cross-reactivity with Non-human primate.

Specificity

Detects a band at approximately 140 kDa.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RIP140 Antibody

Western Blot: RIP140 Antibody [NB110-5122]

Western Blot: RIP140 Antibody [NB110-5122]

Western Blot: RIP140 Antibody [NB110-5122] - Analysis of recombinant human.

Applications for RIP140 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Immunoprecipitation

1:10 - 1:500

Western Blot

2 ug/ml
Application Notes
ICC/IF usage reported in scientific literature (PMID: 7641693).

Reviewed Applications

Read 1 review rated 3 using NB110-5122 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RIP140

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Receptor Interacting Protein 140 (RIP 140) has been shown to enhance estrogen receptor transcriptional activity through the AF2 activation domain in an agonist dependent manner and has also been implicated to be involved in other steroid receptor pathways, including the retinoid pathway. RIP 140 has recently been shown to interact with peroxisome proliferator-activated receptor-alpha (PPAR alpha) and has been proposed to competitively inhibit PPAR alpha interaction with Steroid Receptor Coactivator-1 (SRC-1).

Alternate Names

10RIP140Receptor-interacting protein 140, FLJ77253, nuclear receptor interacting protein 1, nuclear receptor-interacting protein 1, receptor interacting protein 140

Entrez Gene IDs

8204 (Human)

Gene Symbol

NRIP1

Additional RIP140 Products

Product Documents for RIP140 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for RIP140 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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