RUNX1/CBFA2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2044

Novus Biologicals, part of Bio-Techne
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NB100-2044
NB100-2044SS
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all RUNX1/CBFA2 Antibodies »

Product Specifications

Immunogen

Rabbit anti-AML1 polyclonal antibody was raised against a peptide corresponding to a sequence that is homologous in AML1 and AML1/ETO (amino acids 231 to 245 of human origin).

Localization

Nuclear

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

49 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RUNX1/CBFA2 Antibody

Western Blot: RUNX1/CBFA2 Antibody [NB100-2044]

Western Blot: RUNX1/CBFA2 Antibody [NB100-2044]

Western Blot: RUNX1/CBFA2 Antibody [NB100-2044] - Used at 5 ug/ml to analyze AML1 in (A) human Ramosand (B) mouse Raw cell lysate.

Applications for RUNX1/CBFA2 Antibody

Application
Recommended Usage

Western Blot

2-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RUNX1/CBFA2

AML1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. AML1 translocation is frequently observed in acute myeloid leukemia. It is a key transactivator of tissue-specific genes of the hematopoietic and bone lineages.

Long Name

Runt-related Transcription Factor 1

Alternate Names

AML1, CBFA2

Entrez Gene IDs

861 (Human); 12394 (Mouse)

Gene Symbol

RUNX1

UniProt

Q01196

Additional RUNX1/CBFA2 Products

Product Documents for RUNX1/CBFA2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RUNX1/CBFA2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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