SAT1 Antibody [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-41622V

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat, Porcine, Bovine, Chicken, Goat, Xenopus

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SAT1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to a C-terminal region within residues 100-171 of human SAT1. [Swiss-Prot# P21673]

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Zebrafish (86%).

Localization

Cytoplasm.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for SAT1 Antibody [DyLight 405]

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SAT1

SAT1 or spermidine/spermine N(1)-acetyltransferase 1 (also called SSAT, diamine acetyltransferase 1 and putrescine acetyltransferase) is a homodimeric cytoplasmic enzyme which belongs to acetyltransferase family and catalyzes acetylation of polyamines. SAT1's substrate specificity order is: norspermidine = spermidine >spermine > N(1)-acetylspermine > putrescine, and its activity is highly regulated that allows a fine attenuation of the intracellular polyamines concentrations via acetylation or polyamine export. Polyamines such as putrescine, spermidine and spermine are implicated in the regulation of cellular growth/proliferation (increased levels leads to cancer progression) and their levels are controlled by several catabolic enzymes which includes such as SAT1, APAO (acetylpolyamine oxidase) and SMO (spermine oxidase). Enhanced SSAT expression has been shown to be associated with apoptosis in cancer cells and SSAT was shown to decrease the expression of anti-apoptosis-related signaling proteins AKT and mTOR. SAT1 has also been implicated in the neurobiology of suicide and decreased SAT1 expression has been observed in several brain regions in suicide completers. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX).

Alternate Names

DC21, diamine acetyltransferase 1, diamine N-acetyltransferase 1, EC 2.3.1.57, KFSD, Polyamine N-acetyltransferase 1, Putrescine acetyltransferase, SAT, Spermidine/spermine N(1)-acetyltransferase 1, spermidine/spermine N1-acetyltransferase, spermidine/spermine N1-acetyltransferase 1, spermidine/spermine N1-acetyltransferase alpha, SSAT-1, SSATKFSDX

Gene Symbol

SAT1

Additional SAT1 Products

Product Documents for SAT1 Antibody [DyLight 405]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SAT1 Antibody [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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