Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SCO2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human SCO2. The immunogen is located within the last 50 amino acids of SCO2. Amino Acid Squence: DYYGRSRSAEQISDSVRRH

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Bovine (84%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SCO2 Antibody - BSA Free

Western Blot: SCO2 AntibodyBSA Free [NBP1-77274]

Western Blot: SCO2 AntibodyBSA Free [NBP1-77274]

Western Blot: SCO2 Antibody [NBP1-77274] - Analysis in HL60 cell lysate lysate with antibody at (A) 1 and (B) 2 ug/mL.
SCO2 Antibody - BSA Free

Immunohistochemistry: SCO2 Antibody - BSA Free [NBP1-77274] -

Immunohistochemistry: SCO2 Antibody - BSA Free [NBP1-77274] - Immunohistochemistry of SCO2 in human liver tissue with SCO2 antibody at 2.5 u/mL.
SCO2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SCO2 Antibody - BSA Free [NBP1-77274] -

Immunocytochemistry/ Immunofluorescence: SCO2 Antibody - BSA Free [NBP1-77274] - Immunofluorescence of SCO2 in Human Liver tissue with SCO2 antibody at 20 ug/mL.

Applications for SCO2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SCO2

Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.

Alternate Names

cytochrome oxidase deficient homolog 2, MGC125823, MGC125825, protein SCO2 homolog, mitochondrial, SCO cytochrome oxidase deficient homolog 2 (yeast), yeast) homolog 2

Gene Symbol

SCO2

UniProt

O43819 (Human)

Additional SCO2 Products

Product Documents for SCO2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SCO2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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