SCP3/SYCP3 Antibody [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NB300-232V

Submit a review

Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NB300-232AF350

Alexa Fluor 405

NB300-232AF405

Alexa Fluor 488

NB300-232AF488

Alexa Fluor 532

NB300-232AF532

Alexa Fluor 594

NB300-232AF594

Alexa Fluor 647

NB300-232AF647

Alexa Fluor 700

NB300-232AF700

Alexa Fluor 750

NB300-232AF750

Allophycocyanin

NB300-232APC

Biotin

NB300-232B

CoraFluor 1

NB300-232CL1

DyLight 350

NB300-232UV

DyLight 488

NB300-232G

DyLight 550

NB300-232R

DyLight 594

NB300-232DL594

DyLight 650

NB300-232C

DyLight 680

NB300-232FR

DyLight 755

NB300-232IR

FITC

NB300-232F

HRP

NB300-232H

Janelia Fluor 525

NB300-232JF525

Janelia Fluor 549

NB300-232JF549

Janelia Fluor 585

NB300-232JF585

Janelia Fluor 635

NB300-232JF635

Janelia Fluor 646

NB300-232JF646

Janelia Fluor 669

NB300-232JF669

mFluor Violet 450 SE

NB300-232MFV450

mFluor Violet 500 SE

NB300-232MFV500

mFluor Violet 610 SE

NB300-232MFV610

PE

NB300-232PE

PerCP

NB300-232PCP

Forumulation

Catalog #

BSA Free

NB300-232

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Chicken, Feline, Parasite

Applications

Immunoblotting, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SCP3/SYCP3 Antibodies »

Product Summary for SCP3/SYCP3 Antibody [DyLight 405]

Immunogen

A synthetic peptide made to the C-terminal region of the human SCP3 protein. [UniProt# Q8IZU3]

Reactivity Notes

Chicken reactivity reported in scientific literature (PMID: 26096940). Parasite, and Feline reactivity reported in scientific literature (PMID: 27084479). Human reactivity has been observed in IHC. Human reactivity reported in scientific literature (PMID: 29231814).

Localization

Nuclear

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for SCP3/SYCP3 Antibody [DyLight 405]

Application

Recommended Usage

Immunoblotting

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SCP3/SYCP3

SCP3 (Synaptonemal complex protein 3) is a DNA-binding nuclear protein that belongs to XLR/SYCP3 family and is an essential structural component of the transverse filaments of synaptonemal complexes formed between homologous chromosomes during meiotic prophase. Synaptonemal complex develops during prophase of first meiosis, wherein it allows the synapse as well as recombination between maternal - paternal chromosome, and SCP3 is essential to hold cohesin complex between homologous chromosomes, which avoid premature segregation thereby preventing aneuploidies. SCP3 is involved in phosphorylation of HORMAD1 and HORMAD2. It is essential to development of testis (where it is primarily localized) and defective SCP3 may leads to spermatogenic failure type 4 (SPGF4). SCP3 deificient mouse depicts high numbers of aneuploidies in oocytes and offspring. SCP3 is also expressed in certain malignancies including human acute lymphatic leukemias, cervical cancer cells, lung cancer cells etc.

Long Name

Synaptonemal Complex Protein 3

Alternate Names

COR1, SYCP3

Gene Symbol

SYCP3

Additional SCP3/SYCP3 Products

Product Documents for SCP3/SYCP3 Antibody [DyLight 405]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for SCP3/SYCP3 Antibody [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews