PAI-1, PAI-2 and PAI-3 (plasminogen activator inhibitor-1, -2 and -3) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 regulate uPA (urokinase-type plasminogen activator) and TPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. PAI-3 inhibits plasminogen activators as well as activated protein C. PAI-3 is secreted in plasma, but is also expressed in liver.

Alternate Names

PAI-3, PCI

Gene Symbol

SERPINA5

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Product Specific Notices for Serpin A5/Protein C Inhibitor Antibody (OTI1C4) [Janelia Fluor® 669]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Serpin A5/Protein C Inhibitor Antibody (OTI1C4) [Janelia Fluor® 669]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-74100JF669

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Product Summary for Serpin A5/Protein C Inhibitor Antibody (OTI1C4) [Janelia Fluor® 669]

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Background: Serpin A5/Protein C Inhibitor

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Additional Serpin A5/Protein C Inhibitor Products

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Product Specific Notices for Serpin A5/Protein C Inhibitor Antibody (OTI1C4) [Janelia Fluor® 669]

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