Serum Amyloid A1 Antibody (3C11-2C1)

Novus Biologicals, part of Bio-Techne | Catalog # H00006288-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 3C11-2C1

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Serum Amyloid A1 Antibodies »

Product Specifications

Immunogen

SAA1 (AAH07022, 1 a.a. ~ 122 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAADEWGRSGKDPNHFRPAGLPEKY

Localization

Expressed by the liver; secreted in plasma.

Specificity

SAA1 - serum amyloid A1

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Serum Amyloid A1 Antibody (3C11-2C1)

Western Blot: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01]

Western Blot: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01]

Western Blot: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01] - SAA1 monoclonal antibody (M01), clone 3C11-2C1. Analysis of SAA1 expression in human spleen.
Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01]

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01]

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01] - Analysis of monoclonal antibody to SAA1 on formalin-fixed paraffin-embedded human colon adenocarcinoma tissue. Antibody concentration 1 ~ 10 ug/ml.
ELISA: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01]

ELISA: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01]

ELISA: Serum Amyloid A1 Antibody (3C11-2C1) [H00006288-M01] - Detection limit for recombinant GST tagged Serum Amyloid A1 is 1 ng/ml as a capture antibody.

Applications for Serum Amyloid A1 Antibody (3C11-2C1)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against tissue lysate and recombinant protein for WB. It has been used for IHC-P and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Serum Amyloid A1

The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis. Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils, which are derived from different proteins. Almost all patients with amyloidosis have some level of renal disorders. The immunoperoxidase technique has the advantage of being able to detect amyloid in formalin-fixed paraffin embedded tissues and is a very specific method for identifying amyloid fibril proteins. Small and minute amounts of amyloid can be detected with both Amyloid P (ab688) and Amyloid A antibodies, and thus could allow earlier treatment before organ damage has occurred.

Alternate Names

PIG4, SAA1

Entrez Gene IDs

6288 (Human)

Gene Symbol

SAA1

OMIM

104750 (Human)

UniProt

AAH07022 (Human)

Additional Serum Amyloid A1 Products

Product Documents for Serum Amyloid A1 Antibody (3C11-2C1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Serum Amyloid A1 Antibody (3C11-2C1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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