SH2D1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1895

Novus Biologicals, part of Bio-Techne
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NB100-1895
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SH2D1A Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-HKRYFRKIKN corresponding to internal region according to NP_002342.1, NP_001108409.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SH2D1A Antibody

Western Blot: SH2D1A Antibody [NB100-1895]

Western Blot: SH2D1A Antibody [NB100-1895]

Western Blot: SH2D1A Antibody [NB100-1895] - Analysis of SH2D1A in Human Thymus lysate using antibody at 0.3ug/ml.
Western Blot: SH2D1A Antibody [NB100-1895]

Western Blot: SH2D1A Antibody [NB100-1895]

Western Blot: SH2D1A Antibody [NB100-1895] - HEK293 overexpressing SH2D1A and probed with (mock transfection in first lane).

Applications for SH2D1A Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

0.3 - 1 ug/ml
Application Notes
IP: An anonymous customer has reported usage under native conditions. WB: Approx. 16 kDa band observed in human thymus lysates (calculated MW of 14.2x kDa band according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx. 16 kDa is observed. This band is not observed in the non-transfected HEK293.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SH2D1A

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Alternate Names

DSHP, EBVS, IMD5, LYP, MTCP1, XLP, XLPD

Entrez Gene IDs

4068 (Human); 20400 (Mouse); 501502 (Rat)

Gene Symbol

SH2D1A

UniProt

NP_002342.1 (Human)

Additional SH2D1A Products

Product Documents for SH2D1A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SH2D1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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