SH2D1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-40783

Novus Biologicals, part of Bio-Techne
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NB100-40783
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Porcine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SH2D1A Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QYPVEKKSSARSTQ corresponding to internal region according to NP_002342.1, NP_001108409.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SH2D1A Antibody

Western Blot: SH2D1A Antibody [NB100-40783]

Western Blot: SH2D1A Antibody [NB100-40783]

Western Blot: SH2D1A Antibody [NB100-40783] - Analysis of SH2D1A using NB100-40783 at 0.2 ug/ml in Human Lymph Node lysate (35ug protein in RIPA buffer).
Western Blot: SH2D1A Antibody [NB100-40783]

Western Blot: SH2D1A Antibody [NB100-40783]

Western Blot: SH2D1A Antibody [NB100-40783] - HEK293 overexpressing SH2D1A and probed with (mock transfection in first lane).

Applications for SH2D1A Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.2 - 0.6 ug/ml
Application Notes
IP: An anonymous customer has reported usage under native conditions. WB: Approx. 16 kDa band observed in human lymph node lysates (calculated MW of 14.2 kDa band according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx. 17 kDa is observed. This band is not observed in the non-transfected HEK293.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SH2D1A

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Alternate Names

DSHP, EBVS, IMD5, LYP, MTCP1, XLP, XLPD

Entrez Gene IDs

4068 (Human)

Gene Symbol

SH2D1A

UniProt

NP_002342.1 (Human)

Additional SH2D1A Products

Product Documents for SH2D1A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SH2D1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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