SH2D1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-25134

Novus Biologicals, part of Bio-Techne
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NBP3-25134
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SH2D1A Antibodies »

Product Specifications

Immunogen

This antibody has been engineered to specifically recognize the recombinant protein SH2D1A using the following amino acid sequence: AVAVYHGKISRETGEKLLLATGLDGSY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SH2D1A Antibody

SH2D1A Antibody Immunocytochemistry/Immunofluorescence: SH2D1A Antibody [NBP3-25134]

Immunocytochemistry/Immunofluorescence: SH2D1A Antibody [NBP3-25134]

Staining of human cell line JURKAT shows localization to cytosol.

Applications for SH2D1A Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 µg/ml
Application Notes
For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SH2D1A

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Alternate Names

DSHP, EBVS, IMD5, LYP, MTCP1, XLP, XLPD

Gene Symbol

SH2D1A

Additional SH2D1A Products

Product Documents for SH2D1A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SH2D1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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