Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SHBG Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid peptide near the center of human SHBG. The immunogen is located within amino acids 220 - 270 of SHBG. Amino Acid Squence: AEFNLRDIPQPHAEPW

Specificity

At least three isoforms of SHBG are known to exist; this antibody will detect all three isoforms.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

35 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SHBG Antibody - BSA Free

Western Blot: SHBG AntibodyBSA Free [NBP2-41294]

Western Blot: SHBG AntibodyBSA Free [NBP2-41294]

Western Blot: SHBG Antibody [NBP2-41294] - Western blot analysis of SHBG in human liver tissue lysate with SHBG antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry: SHBG Antibody - BSA Free [NBP2-41294]

Immunohistochemistry: SHBG Antibody - BSA Free [NBP2-41294]

Immunohistochemistry: SHBG Antibody [NBP2-41294] - SHBG in mouse liver tissue with SHBG antibody at 20 ug/ml.
SHBG Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SHBG Antibody - BSA Free [NBP2-41294] -

Immunocytochemistry/ Immunofluorescence: SHBG Antibody - BSA Free [NBP2-41294] - Immunofluorescence of SHBG in mouse liver tissue with SHBG antibody at 20 u/ml.
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Applications for SHBG Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SHBG

The gene encodes an EF hand-containing small calcium binding protein. It is an integral subunit component of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits. It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface. It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. It maps to 5q35.1 region of human chromosome. Alternative splicing results in multiple transcript variant encoding different isoforms. Isoform 1 and isoform 2 are expressed in brain and kidney.

Long Name

Sex Hormone-binding Globulin

Alternate Names

ABP

Gene Symbol

SHBG

Additional SHBG Products

Product Documents for SHBG Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHBG Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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