SHIP Antibody (SHIP-02) [PE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-45077PE

Novus Biologicals, part of Bio-Techne
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NBP1-45077PE
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NBP1-45077
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Key Product Details

Species Reactivity

Human, Mouse

Applications

CyTOF-ready, Flow (Intracellular), Flow Cytometry, Western Blot

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # SHIP-02

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SHIP Antibodies »

Product Specifications

Immunogen

Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.

Reactivity Notes

Cross reacts with Human.

Specificity

The antibody SHIP-02 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for SHIP Antibody (SHIP-02) [PE]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow (Intracellular)

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHIP

SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3, 4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).

Long Name

SH2-containing Inositol Phosphatase

Alternate Names

INPP5D

Gene Symbol

INPP5D

Additional SHIP Products

Product Documents for SHIP Antibody (SHIP-02) [PE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHIP Antibody (SHIP-02) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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