SHP-1 Antibody (CPTC-PTPN6-2) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08900JF635

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Western Blot

Label

Janelia Fluor 635

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # CPTC-PTPN6-2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SHP-1 Antibodies »

Product Summary for SHP-1 Antibody (CPTC-PTPN6-2) [Janelia Fluor® 635]

Immunogen

Recombinant human full-length SHP-1 protein (Uniprot: P29350)

Localization

Cytoplasm, Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Applications for SHP-1 Antibody (CPTC-PTPN6-2) [Janelia Fluor® 635]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-1

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

Long Name

Src Homology Region 2 Domain Phosphatase 1

Alternate Names

HCPH, PTP1C, PTPN6, SHP1

Gene Symbol

PTPN6

Additional SHP-1 Products

Product Documents for SHP-1 Antibody (CPTC-PTPN6-2) [Janelia Fluor® 635]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SHP-1 Antibody (CPTC-PTPN6-2) [Janelia Fluor® 635]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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