SHP-2/PTPN11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42920

Novus Biologicals, part of Bio-Techne
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NBP2-42920
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Key Product Details

Species Reactivity

Virus

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SHP-2 Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of SHP-2/PTPN11 (Dengue virus 2 (strain 16681 PDK 53)). The exact sequence is proprietary.

Reactivity Notes

Dengue Virus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SHP-2/PTPN11 Antibody

Western Blot: SHP-2/PTPN11 Antibody [NBP2-42920]

Western Blot: SHP-2/PTPN11 Antibody [NBP2-42920]

Western Blot: SHP-2/PTPN11 Antibody [NBP2-42920] - Non-infected (-) and infected (+) BHK-21 whole cell extracts (15 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Dengue virus NS1 protein antibody diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: SHP-2/PTPN11 Antibody [NBP2-42920]

Immunocytochemistry/ Immunofluorescence: SHP-2/PTPN11 Antibody [NBP2-42920]

Immunocytochemistry/Immunofluorescence: SHP-2/PTPN11 Antibody [NBP2-42920] - Analysis of Denque virus 2-infected BHK-21, using NS1 (Dengue virus) antibody at 1:2000 dilution.

Applications for SHP-2/PTPN11 Antibody

Application
Recommended Usage

ELISA

1:100 - 1:2000

Immunocytochemistry/ Immunofluorescence

1:1000-1:2000

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: SHP-2

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Gene Symbol

PTPN11

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for SHP-2/PTPN11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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