SHP-2 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
56 results for "SHP-2" in Products
56 results for "SHP-2" in Products
SHP-2 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
Shp2 (PTPN11) inhibitor
Chemical Name: | 4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt |
Purity: | ≥98% (HPLC) |
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, Simple Western, ICC |
Source: | E. coli |
Accession #: | NP_002825.3 |
Applications: | EnzAct |
Reactivity: | Human, Mouse, Rat |
Details: | Rat IgG2b Monoclonal Clone #255509 |
Applications: | WB, KO |
Reactivity: | Human, Mouse, Rat |
Details: | Goat IgG Polyclonal |
Applications: | WB, KO |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #6D9 |
Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
Reactivity: | Human, Mouse, Rat |
Details: | Goat IgG |
Applications: | WB |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, KO |
Reactivity: | Human, Mouse, Rat, Canine |
Details: | Mouse IgG2A Monoclonal Clone #OTI3F2 |
Applications: | WB, Flow |
Protein tyrosine phosphatase inhibitor
Chemical Name: | Trisodium vanadate |
Substrate for PTP1B, TC-PTP, SHP-2, and Tyrosine Phosphatase
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ELISA, ICC/IF, IP, KO |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Monoclonal Clone #SR2126 |
Applications: | WB, ICC/IF, IP |
Non-competitive protein tyrosine phosphatase inhibitor
Chemical Name: | 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
Purity: | ≥98% (HPLC) |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, ELISA, ICC/IF, Flow |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #S08-3G2 |
Applications: | IHC, WB |
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
Reactivity: | Human |
Details: | Mouse IgG Polyclonal |
Applications: | WB, Func |
Recombinant monoclonal antibody expressed in HEK293F cells
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #6G11 |
Applications: | IHC, WB, ELISA |
Reactivity: | Virus |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ELISA, ICC/IF |
Reactivity: | Human, Mouse, Rat |
Details: | Mouse IgG1 Monoclonal Clone #M163 |
Applications: | WB |
Recombinant monoclonal antibody expressed in HEK293F cells
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #2E2 |
Applications: | WB, ELISA, IP |
Recombinant monoclonal antibody expressed in HEK293F cells
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #7A1 |
Applications: | WB, ELISA |
Applications: | WB |
Reactivity: | Human, Mouse, Rat, Canine |
Details: | Mouse IgG2A Monoclonal Clone #OTI3F2 |
Applications: | WB, Flow, CyTOF-ready |