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Siglec-7/CD328 Antibody (C2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-43436

Novus Biologicals, part of Bio-Techne
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NBP3-43436

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Lambda Clone # C2

Concentration

1 mg/ml

Product Specifications

Immunogen

Immunized with recombinant Human Siglec-7/CD328 (Uniprot#: Q9Y286; Gly18~Pro191)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Lambda

Applications for Siglec-7/CD328 Antibody (C2)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

5-20 ug/mL

Immunohistochemistry

5-20 ug/mL

Western Blot

0.01-2ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01M PBS, pH7.4, 50% glycerol.

Preservative

0.05% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Siglec-7/CD328

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyllactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked bycis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptorupon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) thatblock signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killercells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towardsmyelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

Long Name

Sialic Acid Binding Ig-like Lectin 7

Alternate Names

AIRM1, CD328, QA79, Siglec7

Gene Symbol

SIGLEC7

Additional Siglec-7/CD328 Products

Product Documents for Siglec-7/CD328 Antibody (C2)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Siglec-7/CD328 Antibody (C2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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