Sin1/MAPKAP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89568

Novus Biologicals, part of Bio-Techne
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NBP1-89568
NBP1-89568-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (97%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Sin1/MAPKAP1 Antibodies »

Product Summary for Sin1/MAPKAP1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Sin1/MAPKAP1 Antibody

Immunocytochemistry/ Immunofluorescence: Sin1/MAPKAP1 Antibody [NBP1-89568]

Immunocytochemistry/ Immunofluorescence: Sin1/MAPKAP1 Antibody [NBP1-89568]

Immunocytochemistry/Immunofluorescence: Sin1/MAPKAP1 Antibody [NBP1-89568] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NBP1-89568]

Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NBP1-89568]

Immunohistochemistry-Paraffin: Sin1/MAPKAP1 Antibody [NBP1-89568] - Staining of human heart muscle shows moderate cytoplasmic positivity in myocytes.

Applications for Sin1/MAPKAP1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF,Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sin1/MAPKAP1

Sin1 is a novel component of the eukaryotic SAPK pathway. Sin1 and the H3 and H4 histones interact genetically, with the C terminus of Sin1 physically associating with components of the SWI-SNF complex. This interaction is blocked by the N-terminal half of the protein in full length Sin1. It has been proposed that Sin1 acts as a regulatable bridge between the SWI-SNF complex and the nucleosome Sin1 is also required for effective transcription via the AP-1 factor Pap1, but does not prevent its nuclear translocation. Sin1 is a novel component of the eukaryotic SAPK pathway.

Long Name

Mitogen-Activated Protein Kinase Associated Protein 1

Alternate Names

JC310, MAPKAP1, MIP1

Gene Symbol

MAPKAP1

Additional Sin1/MAPKAP1 Products

Product Documents for Sin1/MAPKAP1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Sin1/MAPKAP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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