SIX5 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85009

Novus Biologicals, part of Bio-Techne
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NBP1-85009
NBP1-85009-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Rat (90%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SIX5 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLP

Reactivity Notes

Mouse reactivity reported from a verified customer review.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SIX5 Antibody

Immunohistochemistry-Paraffin: SIX5 Antibody [NBP1-85009]

Immunohistochemistry-Paraffin: SIX5 Antibody [NBP1-85009]

Immunohistochemistry-Paraffin: SIX5 Antibody [NBP1-85009] - Moderately differentiated mouse adenocarcinomas show moderate nuclear Six5 expression. IHC-P image submitted by a verified customer review.
Immunohistochemistry-Paraffin: SIX5 Antibody [NBP1-85009]

Immunohistochemistry-Paraffin: SIX5 Antibody [NBP1-85009]

Immunohistochemistry-Paraffin: Six5 Antibody [NBP1-85009] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Applications for SIX5 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Reviewed Applications

Read 1 review rated 5 using NBP1-85009 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIX5

Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.

Alternate Names

BOR2, DM locus-associated homeodomain protein, DMAHPsine oculis homeobox homolog 5 (Drosophila), dystrophia myotonica-associated homeodomain protein, homeobox protein SIX5, sine oculis homeobox (Drosophila) homolog 5, Sine oculis homeobox homolog 5, SIX homeobox 5

Gene Symbol

SIX5

Additional SIX5 Products

Product Documents for SIX5 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SIX5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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