SLC6A4/5-HTTLPR/Serotonin transporter Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1892

Novus Biologicals, part of Bio-Techne
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NB100-1892
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SLC6A4/5-HTTLPR Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-LHQGERETWGK corresponding to internal region according to NP_001036.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SLC6A4/5-HTTLPR/Serotonin transporter Antibody

Western Blot: SLC6A4/5-HTTLPR/Serotonin transporter Antibody [NB100-1892]

Western Blot: SLC6A4/5-HTTLPR/Serotonin transporter Antibody [NB100-1892]

Western Blot: SLC6A4/5-HTTLPR/Serotonin transporter Antibody [NB100-1892] - Human Colon lysate, 35 ug protein in RIPA buffer. Antibody at 2 ug/mL. Detection by chemiluminescence.
Immunocytochemistry/ Immunofluorescence: SLC6A4/5-HTTLPR/Serotonin transporter Antibody [NB100-1892]

Immunocytochemistry/ Immunofluorescence: SLC6A4/5-HTTLPR/Serotonin transporter Antibody [NB100-1892]

Immunocytochemistry/Immunofluorescence: SLC6A4/5-HTTLPR/Serotonin transporter Antibody [NB100-1892] - Analysis of paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing vesicle staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Applications for SLC6A4/5-HTTLPR/Serotonin transporter Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

10 ug/mL

Peptide ELISA

Detection limit 1:32000

Western Blot

1 - 3 ug/mL
Application Notes
Use in ICC on PC12 reported by customer review (antibody at 5ug/mL o/n at 4C). WB: Approx. 70 kDa band observed in human colon lysates (calculated MW of 70.3 kDa band according to NP_001036.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SLC6A4/5-HTTLPR

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Long Name

Solute Carrier Family 6 Member 4

Alternate Names

5-HT Transporter, 5-HTT, 5-HTTLPR, 5HTTLPR, OCD1, Serotonin Transporter 1, SERT

Entrez Gene IDs

6532 (Human)

Gene Symbol

SLC6A4

UniProt

NP_001036.1. (Human)

Additional SLC6A4/5-HTTLPR Products

Product Documents for SLC6A4/5-HTTLPR/Serotonin transporter Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SLC6A4/5-HTTLPR/Serotonin transporter Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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