Sodium Potassium ATPase Alpha 3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-37913

Novus Biologicals, part of Bio-Techne
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NBP2-37913
NBP2-37913-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Sodium Potassium ATPase Alpha 3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: DKKDDKDSPKKNKGKERRDLDDLKKE

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (88%), Rat (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Sodium Potassium ATPase Alpha 3 Antibody

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913]

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913]

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913] - Staining of human endometrium shows low expression as expected.
Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913]

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913]

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913] - Staining of human cerebellum shows strong cytoplasmic positivity in cells in molecular layer.
Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913]

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913]

Immunohistochemistry-Paraffin: Sodium Potassium ATPase Alpha 3 Antibody [NBP2-37913] - Staining of human cerebral cortex shows high expression.
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Applications for Sodium Potassium ATPase Alpha 3 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sodium Potassium ATPase Alpha 3

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.

Long Name

Sodium/potassium-transporting ATPase subunit alpha-3

Alternate Names

ATP1A3

Gene Symbol

ATP1A3

UniProt

P13637 (Human)

Additional Sodium Potassium ATPase Alpha 3 Products

Product Documents for Sodium Potassium ATPase Alpha 3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Sodium Potassium ATPase Alpha 3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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