Somatostatin R4/SSTR4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-39022

Novus Biologicals, part of Bio-Techne
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NBP2-39022
NBP2-39022-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Somatostatin R4/SSTR4 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: YATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Somatostatin R4/SSTR4 Antibody

Immunohistochemistry-Paraffin: Somatostatin R4/SSTR4 Antibody [NBP2-39022]

Immunohistochemistry-Paraffin: Somatostatin R4/SSTR4 Antibody [NBP2-39022]

Immunohistochemistry-Paraffin: Somatostatin R4/SSTR4 Antibody [NBP2-39022] - Staining of human stomach shows moderate membrane positivity in glandular cells.

Applications for Somatostatin R4/SSTR4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Somatostatin R4/SSTR4

SSTR4 has been reported to be expressed in brain, gastrointestinal tract, pancreas, and prostate tissues. No ESTs have been identified. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Long Name

Somatostatin Receptor Type 4

Alternate Names

SomatostatinR4, SS4R, SSTR4

Gene Symbol

SSTR4

UniProt

P31391 (Human)

Additional Somatostatin R4/SSTR4 Products

Product Documents for Somatostatin R4/SSTR4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Somatostatin R4/SSTR4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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