Sortilin Antibody (CL6528) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44415

Novus Biologicals, part of Bio-Techne
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NBP3-44415
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BSA Free
NBP2-76501
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Key Product Details

Validated by

Knockout/Knockdown, Orthogonal Validation

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL6528

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all Sortilin Antibodies »

Product Specifications

Immunogen

This antibody was generated using a recombinant protein sequence of Q99523, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Sortilin Antibody (CL6528) - Azide and BSA Free

Sortilin Antibody (CL6528) - Azide and BSA Free Immunohistochemistry-Paraffin: Sortilin Antibody [NBP3-44415]

Immunohistochemistry-Paraffin: Sortilin Antibody [NBP3-44415]

Analysis in human cerebral cortex and tonsil tissues using NBP3-44415 antibody. Corresponding Sortilin RNA-seq data are presented for the same tissues.
Sortilin Antibody (CL6528) - Azide and BSA Free Immunohistochemistry-Paraffin: Sortilin Antibody [NBP3-44415]

Immunohistochemistry-Paraffin: Sortilin Antibody [NBP3-44415]

Staining of human cerebral cortex shows strong cytoplasmic positivity in neurons.
Sortilin Antibody (CL6528) - Azide and BSA Free Immunohistochemistry-Paraffin: Sortilin Antibody [NBP3-44415]

Immunohistochemistry-Paraffin: Sortilin Antibody [NBP3-44415]

Staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.
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Applications for Sortilin Antibody (CL6528) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Centrifuge the vial of lyophilized antibody at 12,000 x g for 20 seconds. Reconstitute by adding sterile, distilled water to achieve a final antibody concentration of 1mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS with Trehalose

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sortilin

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Alternate Names

Gp95, Ntr3, SORT1

Gene Symbol

SORT1

Additional Sortilin Products

Product Documents for Sortilin Antibody (CL6528) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Sortilin Antibody (CL6528) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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