SPG3A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90234

Novus Biologicals, part of Bio-Techne
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NBP1-90234
NBP1-90234-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Predicted:

Rat (98%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SPG3A Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: IPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESE

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28726976).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SPG3A Antibody

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234]

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234]

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining of human skeletal muscle shows low expression as expected.
Immunohistochemistry: SPG3A Antibody [NBP1-90234]

Immunohistochemistry: SPG3A Antibody [NBP1-90234]

Immunohistochemistry: SPG3A Antibody [NBP1-90234] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234]

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234]

Immunohistochemistry-Paraffin: SPG3A Antibody [NBP1-90234] - Staining of human cerebral cortex shows high expression.
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Applications for SPG3A Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SPG3A

SPG3A is encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

Long Name

Atlastin-1

Alternate Names

ATL1, GBP-3, GBP3, hGBP3

Gene Symbol

ATL1

Additional SPG3A Products

Product Documents for SPG3A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SPG3A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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