SREBP1 Antibody (2A4) [Janelia Fluor® 646]
Novus Biologicals, part of Bio-Techne | Catalog # NB600-582JF646
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human, Mouse, Rat, Canine, Chicken, Golden Syrian Hamster, Hamster, Monkey
Applications
Immunohistochemistry-Frozen, Knockout Validated, Simple Western, Western Blot
Label
Janelia Fluor 646
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # 2A4
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
6 His-tag fusion protein of human SREBP1 corresponding to amino acids 301-407. [UniProt# P36956]
Reactivity Notes
Canine reactivity reported in scientific literature (PMID: 23720350). Hamster reactivity reported in scientific literature (PMID: 24393244). Chicken reactivity reported in multiple pieces scientific literature. Monkey reactivity reported in scientific literature (PMID: 26437365).
Localization
Cytoplasmic and nuclear
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Applications for SREBP1 Antibody (2A4) [Janelia Fluor® 646]
Application
Recommended Usage
Immunohistochemistry-Frozen
Optimal dilutions of this antibody should be experimentally determined.
Knockout Validated
Optimal dilutions of this antibody should be experimentally determined.
Simple Western
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: SREBP1
SREBP1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
Long Name
Sterol regulatory element-binding protein 1
Alternate Names
bHLHd1, SREBF1, SREBP-1
Gene Symbol
SREBF1
Additional SREBP1 Products
Product Documents for SREBP1 Antibody (2A4) [Janelia Fluor® 646]
Product Specific Notices for SREBP1 Antibody (2A4) [Janelia Fluor® 646]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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