STAT3 [p Tyr705] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24463

Novus Biologicals, part of Bio-Techne
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NBP2-24463
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse, Rat, Canine, Chicken, Primate

Cited:

Human

Predicted:

Opossum (100%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all STAT3 Antibodies »

Product Specifications

Immunogen

A portion of human STAT3 protein containing a phosphorylated tyrosine residue at position 705 was used as the immunogen for this phospho antibody.

Modification

p Tyr705

Specificity

100% homologous in human (isoform CRA_b).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for STAT3 [p Tyr705] Antibody

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463]

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463]

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463] - Human breast cancer MCF7 cells were treated with control (Con) or Adenosine (Ado) and the expression of phospho-Stat3 was detected. Image from verified customer review.
Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463]

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463]

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463] - Analysis of STAT3 (Tyr705) in recombinant fusion protein containing 1) a phosphorylated tyrosine at position 705 and 2) an unphosphorylated tyrosine at position 705, using STAT3 phospho antibody at 0.1 ug/mL. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463]

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463]

Western Blot: STAT3 [p Tyr705] Antibody [NBP2-24463] - Human breast cancer cells MDA-MB-231 were treated with carboplatin for 72 hours and the expression of p-Stat3 at Y705 and total Stat3 were detected. Image from verified customer review.

Applications for STAT3 [p Tyr705] Antibody

Application
Recommended Usage

Western Blot

reported by customer review

Reviewed Applications

Read 3 reviews rated 4.7 using NBP2-24463 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: STAT3

Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4)

Long Name

Signal Transducer and Activator of Transcription 3

Alternate Names

Acute-phase response factor, APRFMGC16063, DNA-binding protein APRF, FLJ20882, HIES, signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase responsefactor)

Gene Symbol

STAT3

Additional STAT3 Products

Product Documents for STAT3 [p Tyr705] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for STAT3 [p Tyr705] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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