STAT3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38857

Novus Biologicals, part of Bio-Techne
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NBP2-38857
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all STAT3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: EKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for STAT3 Antibody - BSA Free

Western Blot: STAT3 Antibody [NBP2-38857]

Western Blot: STAT3 Antibody [NBP2-38857]

Western Blot: STAT3 Antibody [NBP2-38857] - Analysis in human cell lines A-549 and PC-3 using anti-STAT3 antibody. Corresponding STAT3 RNA-seq data are presented for the same cell lines. Loading control: anti-PPIB.
Immunohistochemistry-Paraffin: STAT3 Antibody [NBP2-38857]

Immunohistochemistry-Paraffin: STAT3 Antibody [NBP2-38857]

Immunohistochemistry-Paraffin: STAT3 Antibody [NBP2-38857] - Staining of human spleen shows moderate cytoplasmic positivity in cells in red pulp.
Immunohistochemistry-Paraffin: STAT3 Antibody [NBP2-38857]

Immunohistochemistry-Paraffin: STAT3 Antibody [NBP2-38857]

Immunohistochemistry-Paraffin: STAT3 Antibody [NBP2-38857] - Staining of human cervix, uterine shows moderate nuclear positivity in squamous epithelial cells.
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Applications for STAT3 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: STAT3

Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4)

Long Name

Signal Transducer and Activator of Transcription 3

Alternate Names

Acute-phase response factor, APRFMGC16063, DNA-binding protein APRF, FLJ20882, HIES, signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase responsefactor)

Gene Symbol

STAT3

UniProt

P40763

Additional STAT3 Products

Product Documents for STAT3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for STAT3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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