Surfactant Protein A Antibody

Immunocytochemistry/ Immunofluorescence: Surfactant Protein A Antibody [NBP2-12928]

Immunocytochemistry/Immunofluorescence: Surfactant Protein A Antibody [NBP2-12928] - GPRC5A deficiency promotes the phosphorylation and acetylation of NF-kB and mediates the elevation of ABCG1 expression in AT2 cells. IF analysis of ABCG1 in the S/TB region of lung tissue from WT or KO mice, (Bar = 100 um). Image collected and cropped by CiteAb from the following publication (www.nature.com/articles/s41388-020-1251-2) licensed under a CC-BY license.

Immunocytochemistry/ Immunofluorescence: Surfactant Protein A Antibody [NBP2-12928]

Immunocytochemistry/Immunofluorescence: Surfactant Protein A Antibody [NBP2-12928] - GPRC5A deficiency promotes NF-kB-mediated ECM1 expression elevation in Lgr5 cells and secreted ECM1-induced AT2 cell enrichment in the S/TB region. IF analysis of AT2 SPA (Surfactant Protein A) cells in the lung S/TB region after KO:Lgr5 cells with ECM1 or p65 knockdown and injected into NOD/SCID mice through tail vein, (Bar = 100 um); Data were collected from three independent experiments with triplicate samples. **P < 0.01; ***P < 0.001. Image collected and cropped by CiteAb from the following publication (www.nature.com/articles/s41388-020-1251-2) licensed under a CC-BY license.

Immunocytochemistry/ Immunofluorescence: Surfactant Protein A Antibody [NBP2-12928] -

Immunocytochemistry/ Immunofluorescence: Surfactant Protein A Antibody [NBP2-12928] - ECM1-alpha 6 beta4-ABCG1 axis is enriched in the S/TB region of the lungs in patients with pneumonia.IF analysis of GPRC5A, SPA/ABCG1, alpha6/ beta4, alpha6/ECM1 & beta4/ECM1 in normal or pneumonic lung tissue samples (a) & the calculation of positive or dual-positive cells in the S/TB region (b), (Bar = 100 µm); c Graphical abstract of the study: GPRC5A deficiency promotes the activation of NF-kB & subsequent expression & secretion of ECM1; the secreted ECM1 interacts with alpha6 beta4 of AT2 cells & induces the activation of NF-kB, which induces the expression of ABCG1. AT2 cells with ABCG1 expression are one of the originating cell populations of lung cancer. Data were collected from three independent experiments with triplicate samples. **P < 0.01; ***P < 0.001. Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/32157214), licensed under a CC-BY license. Not internally tested by Novus Biologicals.