SYK Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86178

Novus Biologicals, part of Bio-Techne
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NBP1-86178
NBP1-86178-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SYK Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SYK Antibody

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178]

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178]

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178] - Staining of human tonsil shows high expression.
Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178]

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178]

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178] - Staining of human liver shows low expression as expected.
Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178]

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178]

Immunohistochemistry-Paraffin: SYK Antibody [NBP1-86178] - Staining in human tonsil and liver tissues using anti-SYK antibody. Corresponding SYK RNA-seq data are presented for the same tissues.

Applications for SYK Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SYK

Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

Long Name

Spleen Tyrosine Kinase

Alternate Names

DKFZp313N1010, EC 2.7.10, EC 2.7.10.2, FLJ25043, spleen tyrosine kinaseFLJ37489, tyrosine-protein kinase SYK

Gene Symbol

SYK

Additional SYK Products

Product Documents for SYK Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SYK Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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